Frederick J . Suchy An - Qiang Sun , Natarajan Balasubramaniyan , Ke Xu ,

cAMP increases liver Na1-taurocholate cotransport by translocating transporter to plasma membranes

SUNIL MUKHOPADHAYAY,1 M. ANANTHANARAYANAN,2 BRUNO STIEGER,3 PETER J. MEIER,3 FREDERICK J. SUCHY,2 AND M. SAWKAT ANWER1 1Departments of Medicine and Pharmacology, Tufts University School of Veterinary Medicine, North Grafton, Massachusetts 01536; 2Department of Pediatrics, Mount Sinai Medical Center, New York, New York 10029; and 3Division of Clinical Pharmacology, Department of Medicine, Univer...

Ameliorates Murine Experimental Colitis Cytoplasm via Phosphorylated SHP-2 Selective Sequestration of STAT1 in the

A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization

The heteromeric membrane protein Organic Solute Transporter alpha/beta is the major bile acid efflux transporter in the intestine. Physical association of its alpha and beta subunits is essential for their polarized basolateral membrane localization and function in the transport of bile acids and other organic solutes. We identified a highly conserved acidic dileucine motif (-EL20L21EE) at the ...

Role of CYP27A in cholesterol and bile acid metabolism.

The CYP27A gene encodes a mitochondrial cytochrome P450 enzyme, sterol 27-hydroxylase, that is expressed in many different tissues and plays an important role in cholesterol and bile acid metabolism. In humans, CYP27A deficiency leads to cerebrotendinous xanthomatosis. To gain insight into the roles of CYP27A in the regulation of cholesterol and bile acid metabolism, cyp27A gene knockout hetero...

Direct methylation of FXR by Set7/9, a lysine methyltransferase, regulates the expression of FXR target genes.

The farnesoid X receptor (FXR) is a ligand (bile acid)-dependent nuclear receptor that regulates target genes involved in every aspect of bile acid homeostasis. Upon binding of ligand, FXR recruits an array of coactivators and associated proteins, some of which have intrinsic enzymatic activity that modify histones or even components of the transcriptional complex. In this study, we show chroma...